This paper presents some of the possibilities for interaction between performers, audiences, and their smart devices, offered by the novel family of musical instruments, the Smart Instruments. For this purpose, some implemented use cases are described, which involved a preliminary prototype of MIND Music Labs' Sensus Smart Guitar, the first exemplar of Smart Instrument. Sensus consists of a guitar augmented with sensors, actuators, onboard processing, and wireless communication. Some of the novel interactions enabled by Sensus technology are presented, which are based on connectivity of the instrument to smart devices, virtual reality headsets, and the cloud.