# Boolean network model of the T-cell receptor signalling pathway from # "A methodology for the structural and functional analysis of signaling and # regulatory networks", S. Klamt, J. Saez-Rodriguez, J. A. Lindquist, L. Simeoni, E. D. Gilles, # JBMC Bioinformatics 7: 56, 2006. # total number of nodes .v 40 # labels of nodes and names of corresponding components # 1 = CD45 # 2 = CD8 # 3 = TCRlig # 4 = TCbind # 5 = PAGCsk # 6 = LCK # 7 = Fyn # 8 = Rlk # 9 = TCRphos # 10 = ZAP70 # 11 = cCbl # 12 = Itk # 13 = LAT # 14 = Gads # 15 = Slp76 # 16 = PLCg_b # 17 = Grb2Sos # 18 = DAG # 19 = PLCg_a # 20 = Ras # 21 = RasGRP1 # 22 = PKCth # 23 = IP3 # 24 = Raf # 25 = MEK # 26 = Ca # 27 = ERK # 28 = SEK # 29 = IKK # 30 = Calcin # 31 = Rsk # 32 = Fos # 33 = JNK # 34 = IkB # 35 = CREB # 36 = Jun # 37 = CRE # 38 = AP1 # 39 = NFkB # 40 = NFAT # As a result of simulation, we get the following 9 attractors: # # 1111101010101000000000000000001101000000 # 1110101010000101100000000000000001100000 # 1111100010000010000100000000000001001000 # 1111001000000000000000010000000001000000 # 1111111010000000000000001000000001000000 # 1111101111000000000000000010000001000000 # Attractor 1 is of length 6 # # 1111101010000000000000000000000001000000 # Attractor 2 is of length 1 # # 1100100000000000000000000000000001000000 # Attractor 3 is of length 1 # # 1011101010000000000000000000000001000000 # Attractor 4 is of length 1 # # 0000100000000000000000000000000001000000 # Attractor 5 is of length 1 # # 0011000000000000000000000000000001000000 # Attractor 6 is of length 1 # # 1000100000000000000000000000000001000000 # Attractor 7 is of length 1 # # 0100100000000000000000000000000001000000 # Attractor 8 is of length 1 # # 0111000000000000000000000000000001000000 # Attractor 9 is of length 1 # 1 = CD45 .n 1 1 1 1 1 # 2 = CD8 .n 2 1 2 1 1 # 3 = TCRlig .n 3 1 3 1 1 # 4 = TCRbind .n 4 2 3 11 10 1 # 5 = PAGCsk .n 5 2 7 4 1- -0 1 # 6 = LCK .n 6 3 1 2 5 110 1 # 7 = Fyn .n 7 3 1 4 6 1-1 1 11- 1 # 8 = Rlk .n 8 1 6 1 1 # 9 = TCRphos .n 9 3 4 6 7 11- 1 --1 1 # 10 = ZAP70 .n 10 3 6 9 11 110 1 # 11 = cCbl .n 11 1 10 1 1 # 12 = Itk .n 12 2 10 15 11 1 # 13 = LAT .n 13 1 10 1 1 # 14 = Gads .n 14 1 13 1 1 # 15 = Slp76 .n 15 1 14 1 1 # 16 = PLCg_b .n 16 1 13 1 1 # 17 = Grb2Sos .n 17 1 13 1 1 # 18 = DAG .n 18 1 19 1 1 # 19 = PLCg_a .n 19 5 8 10 12 15 16 -1111 1 11-11 1 # 20 = Ras .n 20 2 17 21 1- 1 -1 1 # 21 = RasGRP1 .n 21 2 18 22 11 1 # 22 = PKCth .n 22 1 18 1 1 # 23 = IP3 .n 23 1 19 1 1 # 24 = Raf .n 24 1 20 1 1 # 25 = MEK .n 25 1 24 1 1 # 26 = Ca .n 26 1 23 1 1 # 27 = ERK .n 27 1 25 1 1 # 28 = SEK .n 28 1 22 1 1 # 29 = IKK .n 29 1 22 1 1 # 30 = Calcin .n 30 1 26 1 1 # 31 = Rsk .n 31 1 27 1 1 # 32 = Fos .n 32 1 27 1 1 # 33 = JNK .n 33 1 28 1 1 # 34 = Ikb .n 34 1 29 0 1 # 35 = CREB .n 35 1 31 1 1 # 36 = Jun .n 36 1 33 1 1 # 37 = CRE .n 37 1 35 1 1 # 38 = AP1 .n 38 2 32 36 11 1 # 39 = NFkB .n 39 1 34 0 1 # 40 = NFAT .n 40 1 30 1 1